MLB Predictions:

St. Louis Cardinals vs Pittsburgh Pirates at PNC Park in Pittsburgh.

VS

St. Louis Cardinals vs Pittsburgh Pirates

Game starts at Wednesday, April 29, 2026 - 5:40 PM CST, with trading being allowed until Wednesday, April 29, 2026 - 5:28 PM CST

Make your free predictions & come back to see if you've won!

The new MLB season is here! The 2026 MLB season begins with a special matchup between the San Francisco Giants and New York Yankees on March 25, followed by Opening Day on March 26. A major rule change introduces a ball-strike challenge system, giving teams two challenges per game. The 96th All-Star Game is in Philadelphia on July 14, and the regular season runs through Sept. 27.

WHO WILL WIN?

St. Louis Cardinals vs Pittsburgh Pirates